Indicators of endothelial function and systemic immune inflammatory response in patients with chronic heart failure and coexisting primary hypothyroidism

Chronic heart failure is one of the leading causes death globally, affecting 1.5 to 2% total world population and 2.9 3.9% Western European population. often progresses rapidly in coexistence with endocrine pathology, namely hypothyroidism, that results a more rapid development further progression endothelial dysfunction systemic inflammatory response. The aim our research was study levels endothelin-1, C-reactive protein, tumor necrosis factor α their correlation thyroid-stimulating hormone, thyroxine patients chronic coexisting hypothyroidism. There were examined 38 hypothyroidism 42 without serum determined by enzyme-linked immunosorbent assay, while hormone electrochemiluminescence immunoassay. In 2.9, 2.27 times higher than those Group I, there moderate positive between endothelin-1 weak negative endothelin-1. II, no strong protein as well; similar found. found levels. According results, close markers dysfunction, immune response, single